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In vitro and animal data demonstrate enhanced cell survival, matrix production and gene activation when GHK-Cu is combined with light or antioxidant therapies

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Notably, levels returned to baseline after a 1-month washout period, indicating that continuous supplementation is required to maintain elevated levels

Copper also plays a role in mediating the interaction between HIF-1 and HRE to initiate the expression of copper-dependent genes such as VEGF (49)